Chunk #27 — Discussion

Source

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

Embedded

yes

Text

In conclusion, these findings highlight the highly polygenic and complex nature underlying BMD variation, shedding light on the pathophysiological mechanisms underlying fracture susceptibility and harbouring potential for the future identification of drug targets for the treatment of osteoporosis.