This study is part of the GEnetic Factors for OSteoporosis consortium (GEFOS), a coalition of teams of investigators dedicated to identify the genetic determinants of osteoporosis. The discovery samples comprised 17 GWA studies (n=32,961) from populations across North America, Europe, East Asia and Australia, with a variety of epidemiological designs (Supplementary Table 18A) and patient characteristics (Supplementary Table 18B); a subset of which had fracture information (Supplementary Table 18C). Subjects from 34 additional studies with BMD data (n=50,933) were used for replication while association with fracture was tested across 50 studies with fracture information, most of them also used for the BMD analysis (n=31,016 cases and 102,444 controls) (Figure 1 and Supplementary Tables 19A-C and 20A-C). All studies were approved by their institutional ethics review committees and all participants provided written informed consent.
