Using aversive associative learning paradigms, it has been shown that post-training blockade of CB1 receptors in the right BLA increased freezing behavior and ultrasonic vocalizations in a contextual fear-conditioning paradigm in rats (Roche et al., 2007). Along similar lines, Kamprath et al. recently showed that post-training intra-BLA infusions of the CB1 antagonist SR141716 impaired long-term extinction of conditioned freezing in a cue fear-conditioning paradigm in mice (Kamprath et al., 2011). Similarly, Ganon-Elazar and Akirav recently showed that intra-BLA infusion of AM251 either prior to conditioning or prior to extinction training, impaired extinction of inhibitory avoidance learning in rats (Ganon-Elazar and Akirav, 2009). In contrast, these authors found that intra-BLA infusion of Win 55212-2, prior to conditioning, did not affect acquisition or extinction of inhibitory avoidance learning in rats (Ganon-Elazar and Akirav, 2009). Interestingly, intra-BLA Win 55212-2 infusion did prevent: 1) the enhancing effects of platform stress on the acquisition of inhibitory avoidance learning when administered prior to conditioning and 2) the impairment in extinction caused by pre-extinction stress exposure. By means of a similar olfactory-fear conditioning paradigm, Laviolette and co-workers
