Chunk #60 — 1.5 BEHAVIORAL CONSEQUENCES OF CANNABINOID-MEDIATED MODULATION OF AMYGDALA FUNCTION — 1.5.1 Behavioral effects of eCB signaling in the BLA

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Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress.

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With regard to unconditioned anxiety behaviors, unilateral intra-BLA infusions of THC produced an anxiogenic effect in rats measured using the elevated plus-maze (Rubino et al., 2008). In contrast, neither bilateral intra-BLA Win 55212-2, nor intra-BLA AM251 had any effect on locomotor behavior or anxiety measures in the open field assay (Ganon-Elazar and Akirav, 2009).