The studies presented herein were designed to test the hypothesis that exogenous and endogenous cannabinoids reduce anxiety-like behavior in the marble burying test. First, we tested whether the plant-derived cannabinoid THC affected marble burying. Next, we tested the consequences of elevating eCB brain levels on marble burying by administering selective inhibitors of MAGL and FAAH. Finally, we used the CB1 receptor antagonist rimonabant to test whether the observed anxiolytic-like effects of MAGL and FAAH inhibitors occurred via a cannabinoid receptor mechanism of action.
