It is widely acknowledged that only a subset of the human genome that is considered ‘druggable’ is subject to scientific inquiry (1). Since 2014, the National Institutes of Health (NIH) initiative Illuminating the Druggable Genome (IDG), has been working toward the goal of shedding light on understudied protein targets that could be potentially modulated by small molecules or biologics. Pharos and the Target Central Resource Database (TCRD) are open-access resources developed as a part of the IDG program and jointly serve as the knowledge hub for over 20 000 human protein targets (2,3). First introduced and published in the 2017 NAR database issue (4), TCRD collates information from several gene/protein data sources and Pharos serves as a web interface that presents this information to users. Since its initial launch, the Pharos paper was cited in more than 110 times cf. Google Scholar, and the portal is accessed on average by ∼1600 new visitors monthly, with a total of ∼ 425 000 pageviews and >20 000 full TCRD database downloads (as of 3 September 2020). TCRD has been enhanced by inclusion
