previously23. Briefly, the quality control parameters applied included SNP missingness <0.05, subject missingness <0.02; autosomal heterozygosity deviation; SNP missingness of <0.02; and deviation from Hardy–Weinberg equilibrium P < 1 × 10−6. Genotyped data were pre-phased using SHAPEIT24 and imputed using IMPUTE225 and the 1000 Genomes Project reference panel26. Unrelated individuals were identified considering an identity-by-descent proportion <0.125.
