Linkage studies of family-based samples are another valuable source for candidate regions of the genome involved in disease. GWAS panels have much higher SNP density than linkage studies, and provide finer mapping information using large population-based samples. Within each user-specified linkage region, we select small P-value GWAS SNPs at a user-specified threshold, rank them by P-value and select a user-specified number of non-redundant SNPs (based on pairwise LD) that have the smallest P-value (Figure 2B).
