Chunk #43 — Discussion

Source

Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.

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Several candidate genes were supported primarily in one gender such as SP4 (females) and PLEKHA7 (males). PLEKHA7, which encodes a poorly-understood gene (pleckstrin homology domain containing, family A member 7), is associated with systolic blood pressure.62 Sex differences are likely to exist for genetic effects in MDD.