Regional main effects of diagnosis were widespread and in each case reflected reduced functional connectivity in patients (Figure 3, bottom row). At uncorrected levels, the reductions were significant in 50% of regions (n = 39). These effects survived false-positive correction in ~20% of regions (n = 16; Table S1 in Supplement 1). Significant effects were distributed bilaterally, primarily localizing to frontal, temporal, and parietal areas, with an additional reduction in left visual cortex. These findings reflected generalized, context-independent connectivity reductions in patients that were apparent in both task conditions. No cue-by-diagnosis interaction effects survived false-positive correction.
