Chunk #51 — Online Methods — Genome-wide survival association study datasets — (4) Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
The Original cohort of the FHS has been evaluated biennially since 1948, was screened for prevalent dementia and AD in 1974–76 and has been under surveillance for incident dementiaand AD since then57–59. The Offspring have been examined once every 4 years and have been screened for prevalent dementia with a neuropsychological battery and brain MRI60,61. In order to be consistent with the sampling frame for the AGES and CHS samples, we excluded FHS subjects with a baseline age <65 yrs at the time of DNA draw which was in the 1990s. To minimize survival biases, Original cohort and Offspring participants who developed dementia prior to the date of DNA draw were treated as prevalent cases, and subsequent events in the Original cohort occurring prior to December 2006 were included in the incident analyses.
