AUD and AD GWAS summary statistics were available in two datasets. AD case/control data came from the PGC-SUD (Walters et al., 2018). Cases were defined as meeting criteria for a DSM-IV (American Psychiatric Association, 1994) [DSM-III-R (American Psychiatric Association, 1987) for one study] diagnosis of AD and all controls were alcohol exposed. The PGC-SUD AD phenotype contributed to both EA (N = 46 568) and AA (N = 6280) analyses. AUD case/control status was used from the MVP dataset, defined as ICD-9 or ICD-10 codes for dependence or abuse as obtained from the Veteran’s Affairs electronic health records (EHR); participants with at least one inpatient or two outpatient alcohol-related ICD-9/10 codes (from 2000–2018) were considered AUD cases (Kranzler et al., 2019). AUD case/control status in MVP is available for EA (N = 267 391) and AA (N = 56 648) samples.
