Alcohol consumption-related GWASs summary statistics were available for a number of phenotypes. Specifically, a measure of average DPW came from the GSCAN consortium and the UKB (Liu et al., 2019) available in EA samples only. DPW was defined as the average number of drinks a participant reported drinking each week, aggregated across all types of alcohol. In studies that reported binned response ranges (e.g. 1–4 drinks), the midpoint of the range was used (Liu et al., 2019). Summary statistics for DPW within UKB and GSCAN were examined combined (N = 941 280) as well as separately (GSCAN: N = 526 937; UKB: N = 414 343). The AUDIT (Saunders, Aasland, Babor, De la Fuente, & Grant, 1993) was available in multiple forms and studies. General consumption was measured using the AUDIT-C subscale, which consists of the first three items of the AUDIT and measures past-year typical quantity and frequency of drinking as well as one item measuring frequency of heavy/binge drinking (Bush, Kivlahan, McDonell, Fihn, & Bradley, 1998). AUDIT-C data were available in two datasets, from the EHR data of
