Chunk #16 — Results — RNA levels for Chromosome 4p12 GABAA Genes are Correlated and Identify Two Clusters of iPSC Lines

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GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.

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RT-qPCR analysis revealed a significant correlation of RNA expression among the four consecutive chr4p12 GABAA subunit genes (GABRG1, GABRA2, GABRA4, and GABRB1) in iPSC-derived neural cultures (Table 1). This suggests that AD-associated genetic variation in GABRA2 may have regional effects on the expression of all four GABAA subunit genes. There were no correlations between RNA levels for any of the chr4p12 GABAA genes and GABRD (chr1p36, encoding the GABAA δ subunit), or RBFOX3 (chr17q25, encoding NeuN).