The ontological gene categories affected by cAMP/BDNF/GDNF, FGFR1(SP-/NLS)(TK-) and/or FGFR1(SP-/NLS) included also general multicellular organism development, morphogenesis, organ, cardiovascular, and limb development, cell–cell signaling, retinoic acid, and 2nd messenger signal transduction (Table 2). These findings match the widespread gene targeting by nFGFR119,29 and its proposed pan-ontogenic function20. Also, consistent with the established transcriptional functions of nFGFR118, genes which were affected by FGFR1(SP-NLS)(TK-) and FGFR1(SP-/NLS) overrepresented the functional category of RNA PolII-mediated transcription (Table 2).
