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Chunk #5 — INTRODUCTION

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Gene expression changes in the ventral hippocampus and medial prefrontal cortex of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking.
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(McClintick et al., 2015), and the periaqueductal gray (PAG) (McClintick et al., 2016) of these animals. Given the decreases in volume of both hippocampus (De Bellis et al., 2000) and prefrontal cortex (De Bellis et al., 2005) after heavy alcohol use in adolescence, the effects of chronic drinking on memory (Weissenborn & Duka, 2003; White et al., 2000), and the increased impulsivity of P rats (Beckwith & Czachowski, 2014, 2016), here we examined the transcriptome of the ventral hippocampus and medial prefrontal cortex following adolescent binge-like alcohol drinking by alcohol-preferring (P) rats.