In the last couple of years several genome-wide association studies (GWAS) have been published to reveal additional host genetic factors that are associated with HIV-1 control. Fellay et al published two single nucleotide polymorphisms (SNP) on chromosome 6, one located in HCP5 (rs2395029) and in high linkage disequilibrium (LD) with HLA-B57, and one at position -35 in the HLA-C gene region (rs9264942), to be associated with a lower viral load set-point [14], [15], which could be confirmed by us and others [16], [17]. Other GWAS confirmed the important role of the HLA region on chromosome 6 in the clinical course of HIV-1 infection, and found potentially interesting additional associations which need confirmation in other cohorts [18]–[23].
