Although HIV-1 viral load is established as a good predictor for AIDS disease progression [24], [25], several studies have shown that it is not the sole determinant for variation in disease progression and CD4+ T-cell depletion [26]–[28]. To reveal additional host genetic factors that are associated with the clinical course of HIV-1 infection, we designed a GWAS in the Amsterdam Cohort Studies (ACS) on HIV-1 infection and AIDS and examined the association between SNPs and the time between seroconversion and AIDS-diagnosis or AIDS-related death.
