the brain could contribute to alcohol-induced neuropathology. While this may be mediated through activation of the complement pathways, observations that several complement proteins, including C1q and C3b promote phagocytosis [69, 70] and that CR3 regulates amyloid clearance [71–74], suggests that alcohol-induced changes in complement expression may also regulate microglial phagocytosis of amyloid.Table 1Phagosome-related mRNA enriched in alcohol-treated microgliaSymbolName and functionCoro1aCoronin1aCell membrane associated protein that interacts with actin filaments to facilitate cell motility, endocytosis, and phagocytosis. Loss of Coro1a expression or ability to bind to F-actin impairs these processes [53].ATP6ap1ATPase H+ transporting accessory protein 1Component of the H+ transporting vacuolar ATPase present in phagosomes [54]Fcgr1aFc fragment of IgG receptor IaComplexes with leukotriene B4 receptor in lipid rafts, enhances macrophage anti-microblial actions [55]RT1Proteins of the MHC class I family, involved in antigen presentation.CtssCathepsin SPeptidase present in phagolysosomes where it degrades various target proteins [56]CybaCytochrome b-245 alpha chainNcf1Neutrophil cytosolic factor 1Components of the NADPH Oxidase complex, present in phagolysomes.Slc11a1Solute carrier family 11 member a1, also referred to as Nramp1Transmembrane phagosomal divalent cation transporter [57]Mfge8Ligand milk fat globule EGF factor-8Ligand for Itgb5 (integrain subunit beta 5) required for activation of several pathways, including MerTK activation and F-actin recruitment, involved in clearance [58]PsapProsaponinPrecursor of saposins
