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Chunk #27 — Discussion

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Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis.
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a1, also referred to as Nramp1Transmembrane phagosomal divalent cation transporter [57]Mfge8Ligand milk fat globule EGF factor-8Ligand for Itgb5 (integrain subunit beta 5) required for activation of several pathways, including MerTK activation and F-actin recruitment, involved in clearance [58]PsapProsaponinPrecursor of saposins A, B, C, and D, which have roles in lysomal degradation pathways [59]SirpaSignal regulatory protein alphaMacrophage receptor for CD47 which is a broad inhibitor of phagocytosis [60, 61]CalrCalreticulinWhen present on the cell surface acts as a signal to activate macrophage phagocytosis [62]CD300lfMember of the CD300 receptor familyRoles in activating macrophage engulfment by phosphatidylserine signaling [63]PycardPYD And CARD Domain Containing, also referred to as ASC (Apoptosis-Associated Speck-Like)Component of the NLRP3 inflammasome, recently shown to play a role in amyloid deposition. [64]