We next stratified the population according to GPS decile and found a striking gradient with respect to BMI, weight, and prevalence of obesity (Figure 2A–2C). For example, average BMI was 30.0 kg/m2 for those in the top decile of the GPS and 25.2 kg/m2 for those in the bottom decile, a difference of 4.8 kg/m2 (p < 0.0001). Similarly, average weight was 85.3 kilograms for those in the top decile versus 72.2 kilograms for those in the bottom decile, a difference of 13.0 kilograms (p < 0.0001). 43.2% of those in the top decile were obese versus 9.5% of those in the bottom decile (Figure S2). Severe obesity was present in 1,621 of 28,784 (5.6%) of those in the top decile of the GPS versus 69 of 28,834 (0.2%) of those in the bottom decile, corresponding to a 25-fold gradient in risk of severe obesity (p < 0.0001).
