It is worth pointing out that the failure of a gene to appear in any of the association lists should also be viewed with caution. As is the case for single SNP analysis, power and gene coverage mean that in a moderate sized GWAS study, however it is analysed, failure to find evidence for association is not strong evidence for absence of involvement of that gene27. In that context, we simply note that the present analyses provides no support for dysbindin (DTNBP1), neuregulin1 (NRG1), D-amino acid oxidase activator (DAOA), disrupted in schizophrenia 1 (DISC1), or brain derived neurotrophic factor (BDNF), genes which prior to the advent of GWAS studies were among the most prominent candidates for either disorder3.
