The enhanced target synopsis pages have new and sophisticated functionality to explore potential roles of any human target in cancer. Figure 1 and Supplementary Figure S1 show a subset of the dashboard of information available for EGFR, focusing mainly on novel features and functionality. The user is initially presented with an overview of cancer association assessments for their target of interest, visualised in word cloud form and leveraging both the in-depth pharmacological and molecular disease alteration data in canSAR. The clinical component of the cancer-target association score (CTA), allows the rapid assessment of evidence of approved and investigational drugs targeting the protein of interest, for each cancer type (Supplementary Figure S1A). The molecular alteration components of the CTA score capture the frequency, specificity and effect of alterations (mutations, copy number and expression) for each cancer cohort. A word cloud representation shows cancer types with strongest association with the target can be displayed for individual molecular data types as well as the combination of all alterations.
