The user can further explore the cancer-target association evidence by selecting the cancer of their interest from the cancer word cloud. The example shown in Figure 1 and Supplementary Figure S1 is focused on lung cancer. For both approved and investigational drugs targeting EGFR in lung cancer (Supplementary Figure S1B-C), links to the drug chemistry synopsis in canSAR are provided that enable detailed profiling of each compound, together with intervention and clinical trial information. Information on the mutation spectrum, copy number and expression alterations is displayed for patient cohorts pertinent to the selected cancer type, with extensive staging information to allow discovery of potential links to disease progression (Figure 1A, B displaying changes in gene expression and copy number alterations, respectively). Finally, the dependency of the target across a large number of cancer cell lines in systematic genetic screens can be assessed rapidly via a waterfall plot with the cell lines relevant to the selected cancer highlighted in red (Supplementary Figure S1D).
