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Chunk #7 — Influence of Genetic Factors and Ethanol Exposure on DYN/KOR Expression — Basal Differences in DYN/KOR Expression

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Role of the Dynorphin/Kappa Opioid Receptor System in the Motivational Effects of Ethanol.
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nucleus accumbens and caudate putamen than ethanol-preferring C57BL/6 mice (Jamensky and Gianoulakis, 1997). Similarly, DBA/2 mice also exhibited greater DYN-B in nucleus accumbens and striatum relative to C57BL/6 mice (Ploj et al., 2000). However, C57BL/6 mice were reported to have higher KOR binding sites and DYN-A1-13 levels in the amygdala and more DYN-A1-8 in the ventral tegmental area than DBA/2 mice (Jamensky and Gianoulakis, 1997). Thus, differences in DYN/KOR expression between inbred mouse strains may depend on brain region examined as well as differences in peptide vs. receptor measurements.