In the hippocampus, rapid, dynamic changes in network patterns are observed in the hippocampus during memory-guided behavior [31,32] (eg. in Figure 1). Strikingly, some of these network patterns have been shown to be associated with dynamic changes in population activity in PFC. Here, PFC is used to denote the prelimbic and infralimbic regions of the medial prefrontal cortex as well as the anterior cingulate cortex. There are multiple direct and indirect connections between the hippocampus and PFC that can support these interactions. Direct connections to PFC primarily arise from the ventral and intermediate CA1 regions of the hippocampus, with a minority from dorsal CA1 [33]. Indirect connections between the hippocampus and PFC are also routed via other medial temporal lobe (MTL) areas, including the subiculum, entorhinal cortex, peri- and post-rhinal cortex [34], and also through nucleus reuniens [35,36]. Further, the dense interconnectivity between the principal hippocampal layers and throughout the longitudinal axis of the hippocampal formation [37] provides a pathway for coordination of activity throughout these structures.
