These diverse anatomical connections between the regions can support bi-directional interactions [30,38,39]. In different behavioral tasks, task selective responses of prefrontal neurons can be derived from hippocampal inputs [30], and vice versa [38], and direction of interactions can also be dependent on task phase [39]. We reason that such findings provide additional evidence that rather than regarding these regions as modular entities with discrete functions, they should be considered as part of an interacting network that sub serves joint functions necessary for memory-guided behavior. The impact of interregional dialogue and the resulting dynamics therefore needs to be considered, along with the recognition that behavioral context and internal brain state are important parameters that govern functional interactions between the regions. Coordination between these two structures could facilitate the updating of network activity during rapid transitions in behavioral state and cognitive demands that occur during learning and memory-guided behavior. In support of this notion, recent studies have provided evidence that network patterns such as theta oscillations and SWRs represent dynamical states that sub serve synchronization of ensemble activity across regions to support cognitive function.
