no single sample was solely driving the finding. Mania score distributions differed by sample; however, significance was seen across multiple samples and removal of any single sample did not appreciably change the overall result (Supplementary Table 6). The correlation between BP polygenic risk score and mania score was strongest at the high end of the mania distribution, implicating a possible subset of individuals with both high mania scores and high BP polygenic risk scores. To investigate further, we identified a subset of the SCZ cases that included 183 individuals with, and 886 without a schizoaffective disorder diagnosis. Within this subset, schizoaffective individuals had significantly higher mania scores than non-schizoaffective individuals but did not carry significantly higher BP polygenic risk scores. However, this subsample had no significant correlation between BP polygenic risk score and mania score overall leaving us underpowered to assess the affect schizoaffective status has on the overall correlation between BP polygenic risk score and mania score. We additionally sought to understand the effect that individuals with both high BP polygenic score and high manic factor score had on our results. We removed 186 individuals with BP polygenic score and manic factor score one standard deviation from the mean
