Chunk #33 — Results — CSD-PCA Comparisons between Groups

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Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.

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Figure 5 reveals that factor score topographies were similar in patients and controls for nontarget and target stimuli. The novelty vertex source (241) was unique to novels and showed a prominent reduction in depressed patients. In contrast, the mid-line frontal P3 source (343) topography was not unique to novels (i.e., was also prominent for targets), and was equally evident in patients and controls.