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Chunk #9 — Results — Integration of GWAS and eQTL/ mQTL data from fetal and adult brain

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Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases.
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meta-analysis.ChrBPGeneAdult brainFetal braineQTL p valuemQTL p valueeQTL p valuemQTL p value1146399942SPI1Nxxx1.91E−0446664086MTCH21.89E-05xxx46843734NUP1603.88E-04xxx348395716GPX14.93E-05xxx48459884AMT2.07E-04x4.39E−044.47E−011743361331MAP3K14Nxxx2.99E−05The reported genes from the integration analyses survived four different P value thresholds to be nominated as potential causal candidate genes (GWAS P =0.05; FDRSMR-P < =0.2). SMR P-values for the co-localized SNPs are obtained using the Wald test. The superscript N in front of gene indicates the potential candidate causal gene prioritized using current multi-omic analysis.Chr chromosome, BP start position of the gene, Gene candidate causal gene, p value SMR P values for integration of AUD summary statistics with respective eQTL/mQTL annotation from adult or fetal brain). x denotes the missing values either due to non-significant results or sub-threshold expression or methylation values in the respective tissue.