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Chunk #36 — METHODS — Stage 1 GWAS populations

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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
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Thirty-two studies contributed to the Stage 1 GWAS meta-analysis, comprising 87,802 women of White European ancestry. The consortium was made up of populations from the Age, Gene/Environment SusceptibilityStudy(AGES, n=1849), the Amish population (Amish, n=557), the Atherosclerosis Risk in Communities study (ARIC, n=4247), the British 1958 Birth Cohort (B58C-T1DGC and B58C-WTCCC, n=1584), CoLaus (n=2797), deCODE (n=15,864), the Danish National Birth Cohort (DNBC, n=1748), the Estonian Genome Center, University of Tartu (EGCUT, n=987), the European Prospective Investigation into Cancer and Nutrition (EPIC-obesity cases and cohort, n=1840), the Erasmus Rucphen Family Study (ERF, n=1103), the Framingham Heart Study (FHS, n=3801), the Helsinki Birth Cohort (HBCS, n=976), the Health 2000 study (Health 2000 cases and controls, n=922), InCHIANTI (n=597), the Indiana University premenopausal Caucasian women peak BMD study (Indiana, n=1497), the Nurse’s Heath Studies (NHS, n=5360), the Northern Finland Birth cohort (NFBC, n=2648), the Netherlands Twin Register (NTR, n=1051), the Queensland Institute of Medical Research (QIMR, n=3528), the Rotterdam studies (RS1, RS2 and RS3, n=5406), the Study of Addiction: Genetics and Environment (SAGE, n=1376), the SardiNIA study (n=2158), Twins UK I, II and III