Chunk #22 — Results — The effect of age, gender, cause of death, region, PMI and brain pH on RIN-based RNA quality

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Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies.

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Outside of pH and PMI, which were analysed separately, the most important covariates were brain region (explained 9.2% of the variation in RIN number, p = 1.7 × 10−42 ), age (explained an additional 1.1%, p = 4.1 × 10−05 ) and cause of death (explained an additional 1.9%, p = 0.022). Brain bank and gender together explained an additional 0.4% of the variation.