Detection of common CNVRs and initial association analyses were based on two GWAS discovery samples both genotyped by the Affymetrix Genome-Wide Human SNP Array 6.0. The family-based GWAS sample (Sample 1) consists of 424 obesity trios, i.e. one (extremely) obese child or adolescent and both biological parents (Supplementary Material, Table S1). The second GWAS sample (Sample 2) consists of 453 (extremely) obese children and adolescents and 435 normal-weight or lean adult controls (Supplementary Material, Table S1). For replication of the association of certain CNVs with obesity as derived from both GWAS samples, we analysed a third independent sample of 365 obesity trios (Sample 3) which was recruited similarly as the family-based GWAS sample (Supplementary Material, Table S1). Additional array-based replication analyses were performed in a subsample of Sample 3 consisting of 281 obesity trios for which genome-wide genotyping data (Affymetrix Genome-Wide Human SNP Array 6.0) became available very recently (Sample 3a).
