most have data on whether there is any history of tic disorders in the first degree relatives. The TIC Genetics cohort generally has data on tic disorders in second-degree relatives as well. Among the 511 total trios sequenced here, parental clinical data was available for 487 families. Of these, 442 families (90.8%) had no evidence of a tic disorder in either parent. Sibling and second-degree relative histories were available for 278 families. Of these, 206 families (74.1%) had no evidence of a tic disorder in parents or siblings, and 163 families (58.6%) had no evidence of a tic disorder in parents, siblings, or a second degree relative (Table S1).
