For schizophrenia, we replicated and extended our previous findings 12. We found the most significant associations for neurons located in the cortex, hippocampus and striatum (Figure 2A, 3) in multiple independent datasets, and showed that these neuronal cell types can be prioritized among neurons (Figure S9, S16 and S18). These results are consistent with the strong schizophrenia heritability enrichment observed in open chromatin regions from: human dorsolateral prefrontal cortex 54; human cortical, striatal and hippocampal neurons 55; and mouse open chromatin regions from cortical excitatory and inhibitory neurons 56. This degree of replication in independent transcriptomic datasets from multiple groups along with consistent findings using orthogonal open chromatin data is notable, and strongly implicates these cell types in the etiology of schizophrenia.
