To our knowledge, among studies examining relationships between subjective response and impulsivity, ours is the first to utilize data from IV administration and the first involving multiple alcohol doses. Our results suggest that impulsive individuals may experience enhanced reinforcing, stimulant effects and muted aversive, sedative effects. These subjective responses may relate to enhanced risk of alcohol problems among more impulsive people. This pattern of subjective response needs to be replicated and long-term implications of enhanced stimulant and weaker sedative response in impulsive individuals should be addressed in future studies.