A high degree of LD was observed across the GABRA2 gene in the subjects of this study. The estimated pairwise LD (D′) (Lewontin, 1988) values between SNPs 1 to 7 were 1 (SNPs 1 to 2), 1 (2 to 3), 1 (3 to 4), 1 (4 to 5), 0.92 (5 to 6), and 1 (6 to 7). Almost complete LD was observed among these SNPs. A detailed illustration of LD within GABRA2 is presented in Fig. 2. Best estimates generated by Haploview for the 5-marker haplotypes defined by SNPs 1 to 5 identified 3 common haplotypes, TCACA, CTGAG, and TCAAG, which together represented 99.2% of chromosomes. The frequencies of each haplotype were 62.0, 25.9, and 11.3%, respectively.
