SNPs 1, 2, 3, and 7 showed no significant association with the initial response to alcohol (data not shown), whereas SNPs 4 to 6 were significantly associated with the initial response on several subscales in SS. As the distribution of genotypes between SNPs 4 and 5 is identical in all subjects, we combined the results from these 2 SNPs (SNP4 A-allele = SNP5 G-allele; SNP4 C-allele = SNP5 A-allele). Among individuals with ALDH2*1/*2, subjects with 1 or 2 copies of SNP4 C-allele (SNP5 A-allele) had greater increased scores in Anesthetic [F (2, 20) = 5.23, p = 0.015], Dynamic Peripheral [F (2, 22) = 4.14, p = 0.030], and General [F (2, 18) = 4.82, p = 0.021] subscales of SS than those homozygous for SNP4 A-allele (SNP5 G-allele) (Fig. 3B). In individuals with ALDH2*1 /*1, there was a trend for higher scores among SNP4 C-allele (SNP5 A-allele) carriers than SNP4 A-allele (SNP5 G-allele) homozygotes in Stimulant [F (2, 74) = 2.74, p = 0.071] subscale of the BAES (Fig. 4A). In SNP6, the above-mentioned 3 SS subscale scores were
