for higher scores among SNP4 C-allele (SNP5 A-allele) carriers than SNP4 A-allele (SNP5 G-allele) homozygotes in Stimulant [F (2, 74) = 2.74, p = 0.071] subscale of the BAES (Fig. 4A). In SNP6, the above-mentioned 3 SS subscale scores were also statistically significant: In subjects with ALDH2*1/*1, there were significant differences in Anesthetic [F (2, 74) = 3.58, p = 0.033] and Dynamic Peripheral [F (2, 77) = 4.39, p = 0.016] subscale scores among TT, TC, and CC genotypes (Fig. 5A). Among subjects with ALDH2*1 /*2, the increase in Anesthetic [F (2, 20) = 5.24, p = 0.015], Dynamic Peripheral [F (2, 22) = 4.09, p = 0.031], and General [F (2, 18) = 4.84, p = 0.021] subscale scores following alcohol administration was greater in the T-allele carriers than in the C-allele homozygotes (Fig. 5B). Without regard to ALDH2 genotype, all participants showed no significant differences in BAES by the genotype of GABRA2 SNP6 (Fig. 6).
