Protein ID numbers were used to obtain the corresponding Entrez-Gene identifier. Testing for over-representation of Gene Ontology (GO) (Harris et al. 2004; Ashburner et al. 2000) biologic process (BP) and molecular function (MF) categories was performed using the Bioconductor package GOstats (Gentleman 2004; Gentleman et al., 2004). Identification of over-represented GO categories was then accomplished within GOstats using the hypergeometric distribution. Categories, with 5 or more proteins, are listed. Categories were called significant for p < 0.05. Ingenuity® Pathways Analyses (Ingenuity, Inc. www.ingenuity.com) were conducted on proteins that were statistically significant. Ingenuity builds networks based upon information extracted from the scientific literature that is deposited in Ingenuity proprietary database. Network Eligible Molecules are combined into networks that maximize their interconnectedness with each other relative to all molecules they are connected to in the database.
