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Chunk #12 — Novelty P3 in Depressed Patients

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Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.
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these findings in an independent and substantially larger sample (N = 98; 49 depressed patients) using a denser 67-channel recording montage so as to identify and quantify the underlying scalp current generator patterns derived from reference-free CSD-PCA methodology. Findings were compared with analogous CSD-PCA solutions obtained from the previous, smaller sample (N = 40) using a 31-channel montage, and interpreted in the context of solutions obtained for other auditory oddball tasks.