One of the most studied and replicated measures of LR to alcohol has been the use of scales that index how intensely an individual feels the effects of alcohol following a challenge dose that is given in the laboratory. Subjective response to the effects of alcohol lends itself to establishing consilience, because the association between this response and alcohol consumption/breath alcohol concentration is under substantial genetic control [c.f. (Viken et al. 2003;Heath, Martin 1991)]. The most commonly used scale is the Subjective High Assessment Scale (SHAS) (Judd et al. 1977). This scale asks subjects to rate themselves on a number of items including: feeling the effects of alcohol overall; feeling drunk, high, clumsy, confused, dizzy, great, terrible, floating; having difficulty concentrating; and other such items [see (Schuckit et al. 2009)] every 15-30 minutes following alcohol administration, usually for a period of 210 minutes. It has been used in a variety of studies in a number of populations including adult children of alcoholics [aCOAs: see (Schuckit, Gold 1988;Eng et al. 2005;Schuckit et al. 1996)], Asians with the ALDH2*2 allele (Wall et
