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Chunk #27 — Methods — Genome-wide expression and genotyping.

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Tissue-specific genetic control of splicing: implications for the study of complex traits.
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of variability on both an exon and transcript level, and were therefore included in subsequent genetic association analyses as covariates in linear regression models. A combined normalization on both brain tissue samples and PBMCs also was performed on both the exon and transcript level. Principal components analyses were performed for a combined normalization in order to demonstrate the unique expression patterns in cortical tissue and PBMCs.