Haplotype frequencies and agreement with Hardy-Weinberg expectations were predicted using the default settings of PHASE, version 2.1 (based on variation identified from the sequencing of 40 chromosomes). To identify putatively functional variants, we examined regions containing consensus sites for factors known to regulate CRH transcription and also used web-based transcription factor binding site prediction algorithms (TfSitescan, www.ift.org/cgi-bin/ifti/Tfsitescan.pl 21 and Compel Pattern Search 1.0, http://compel.bionet.nsc.ru/FunSite/CompelPatternSearch.html 22).
