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Chunk #39 — Discussion

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Absence of P300 reduction in South African treatment-naïve adolescents with alcohol dependence.
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We examined gender differences in P300 following mixed reports of such effects within AUD samples. Overall, boys had larger P300 complexes than girls. These results are consistent with Hill and Steinhauer (1993) and Steinhauer and Hill (1993), who also reported larger P300 amplitudes in boys. Mixed reports of gender-related differences in P300 in the literature, however, may be due to possible interactions between age and gender on the P300. Specifically, it appears that, during adolescence, boys generally exhibit relatively larger P300 complexes; however, from late adolescence onwards, females tend to have relatively larger P300 complexes (Carlson et al., 2002; Hirayasu et al., 2000; Hoffman and Polich, 1999).