SI. However, across several analyses, there was substantial evidence for interactions of early substance use with sex and race (Table 4). While the main effect of early substance use was not strongly related to onset of SI or SA, males with a history of early substance use that preceded onset of SA were less likely than early substance-using females to report onset of SA (as well as SI for early alcohol use). Furthermore, African-Americans reporting early nicotine and early cannabis use were at 0.31 – 0.70 adjusted odds of onset of SI and SA relative to their European-American counterparts who had used nicotine or cannabis at an early age.
