Chunk #39 — The search for gene variants related to alcohol sensitivity (See Table 1) — Additional genes of potential interest

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A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.

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Glypican 5 (GPC5) (chromosome 13q31.3) modulates cellular signaling in the caudate nucleus, putamen and hippocampus. Variant rs1330469 is potentially related to alcohol-induced ataxia in mice, locomotion in Drosophila, and single dose oral alcohol induced ataxia in humans (Joslyn et al., 2011; Kong et al., 2010; Saunders et al., 1997).