Chunk #38 — The search for gene variants related to alcohol sensitivity (See Table 1) — Additional genes of potential interest

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A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.

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Homologes of human anaplastic lymphoma kinase (ALK) (also known as ALK tyrosine kinase; chromosome 2p22.3) may be associated with resistance to alcohol’s sedative effects in Drosophila, alcohol-induced ataxia in recombinant inbred mice, and with longer alcohol sedation in ALK knockout mice (Lasek et al., 2011a,b). Sequencing of human ALK indicated several variants (e.g. rs17004646) potentially associated with low sensitivity (Lasek et al. 2011b).