that contain a proportion of OPCs 49, 50. These data indicate that comparable shifts in ion channel expression are occurring throughout human oligodendrogenesis in vitro. Our data show that the expression of voltage‐gated K+ channels, I A and I K, is prominent in OPCs in all lines and that the reduction of expression in oligodendrocytes corresponds well to the shifts in membrane current properties. Such data are in accordance with previously observed developmental shifts in I A and I K channel expression in rodent oligodendroglial cells and also prominent expression of such membrane conductances in in vitro mouse PSC‐derived OPCs 48.
