the skeleton. Partial-volume effects and areas of high inter-subject variability were minimized by thresholding values at 0.2. Values from individuals’ nearest relevant tract center were assigned to the skeleton through a perpendicular search for the maximum value within the skeleton. MD, RD, and AD data were analyzed using the same skeleton-projection vectors derived from the FA images (Smith et al., 2007). Voxelwise statistical comparisons were carried out in AFNI using data from each point on the skeleton using independent sample t-tests corrected for multiple comparisons and only clusters > 153 μl with brain-wise p < .05 were interpreted.
